The Workshop Agriculture and Microbiomes towards the Future New Perspectives between Research and Innovation held in Rome on October 18th, 2024 gathered five PRIMA projects (BENEFIT-Med, PROSIT, REVINE, RESCHEDULE, OPTIMUS PRIME) sharing scientific and technical knowledge, as well as experience in public engagement, with the common goal of bringing innovation to the agroecosystems of the most climate -vulnerable regions of the Mediterranean Area.